Multiple Autoimmune Syndrome (MAS), AutoInflammatory Disease and Inflammation

Multiple Autoimmune Syndrome (MAS)For a long time, people who suffered from the seemingly related disorders known as multiple autoimmune syndrome (MAS) and autoinflammatory disease were thought to be hypochondriacs or lazy when they complained to their doctors about their symptoms: skin rashes, chronic fatigue, joint pain, unexplained fevers, chest pain and abdominal pain just to name a few.

Now, doctors and researchers have organized patients and their symptoms into two primary and related groups:

Painful Psoriasis: MAS & AutoInflammatory DiseaseWhile the two categories have distinct differences, they also have commonalities, the primary one being inflammation. With both types of conditions, the body’s immune system is “confused” and attacks itself.

Multiple Autoimmune Syndrome (MAS) occurs when a person has three or more autoimmune diseases simultaneously and one of them is a skin disorder such as psoriasis, scleroderma or vitiligo.

Autoinflammatory disease is also an autoimmune disorder, and comes under a number of different guises:

  • Familial Mediterranean Fever (FMF)
  • Behcet’s disease
  • Neonatal Onset Multisystem Inflammatory Disease (NOMID)
  • Tumor Necrosis Factor (TNF) receptor-associated periodic syndrome (TRAPS)
  • Deficiency of the interleukin-1 (IL-1) receptor antagonist (DIRA)

These inflammatory diseases cause problems that range from skin rashes, soresabdominal pain and joint pain, unexplained fevers, inflamed blood vessels, adrenal insufficiency /fatigue, inflammation (chronic) is at the root of most human diseases and heart failure.

Chronic inflammation is commonly associated with each type of MAS. It is believed the inflammation encourages T-cellsv, intended to defend the immune system for a short-term assault, to stay “on” and attack the body instead. This causes tremendous damage in various areas of the body depending upon which system the T-cells falsely identify as a harmful invader. If the chronic inflammation is in the brain it can contribute to Alzheimer’s or Parkinson’s for example, in the circulation system, heart disease or stroke. If fat cells are chronically inflamed, it begins the process of type 2 diabetes. Inflammation in the gut leads to a host of painful skin disorders, joint diseases and bowel diseases including cancer. Genes become damaged and the immune system’s ability to correctly function is further compromised.

Add into this equation the many toxins present in our modern food chain and environment, plus high-risk behavior such as overeating, a diet high in carbohydrates and bad fats, lack of exercise, smoking, too much alcohol consumption and you have the unhealthy beginnings of MAS. However, there are actions you can take to reclaim your health.

The degree to which multiple autoimmune syndrome and autoinflammatory disease can be remediated, and chronic inflammatory response “turned off”, with lifestyle changes such as an anti-inflammatory diet, supplements and exercise has been area of intense study for several years.

Some of our ProBoost customers have shared two excellent resources written for laymen, that provide enlightening, actionable and scientific information about the tremendous impact of diet, toxins and life choices on our immune system’s function and our health. In fact, one of our customers Endocrinologist gives a copy of the first book to each of her diabetic patients:

  • Clean by Dr. Alejandro Junger, Cardiology & Functional Medicine
  • Grain Brain by Dr. David Perlmutter, Neurology

Multiple Autoimmune Syndrome and AutoInflammatory Disease is not “in your head” or a sentence that you can do nothing about as you will discover in the two books above. No supplement supports healthy immune function like ProBoost Thymic Protein A. Here is a testimonial from a customer whose daughter has MAS.

“My 21 year old daughter has fibro, chronic fatigue, AZOOR, necrobiosis lipoidica, granuloma annulare, and irritable bowel syndrome IBS. We swear that ProBoost has helped with almost all of them. And the best part about ProBoost is it’s natural – no harsh drugs, no side effects. It seems every drug she takes requires yet another to offset the effects of each other. Not so with ProBoost. We are sold!”

– Melissa L. – CustomerOrder Proboost

Here is a link about how Thymic Protein A works to boost the human immune system. To order ProBoost click here

Immune System Dysfunction and Thymic Protein A – Part 2: Look at the Source

High cost of health careIn part 1 of this blog, we talked about the enormous cost of Immune System Dysfunction. But  let’s look at a simple protein, one that our bodies make while we are young and diminishes as we age, that gives us the opportunity to optimize our immune system.

In the treatment of Immune Dysfunction, using thymic protein extracts has been researched since the 1970’s.  Considerable proof has been found that demonstrates that thymic proteins are useful for boosting immune function related to several diseases and disorders including, chronic infections (viral and bacterial), certain types of cancers and some auto-immune disorders.

Supplementation with Thymic Proteins can be used when the body’s own defense mechanisms are attacking self-tissue.  It was also discovered that repeated infections were reduced when sustained thymic proteins were use for a period of at least one year or more. The studies also confirmed that patients improved their immune parameters.

One of the most important indications for Thymic Protein A use in cancer patients, is the management of lymphopenia/leukopenia caused by chemotherapy and radiation treatments. Because of the severe drop in white blood cells, thymic protein use can bring up the white cell counts faster when they do fall or prevent dangerously low levels.  Patients taking thymic protein conclude their treatment with lesser side effects than patients who do not take it.

Clinical studies have shown that Thymic Protein A is indicated in the treatment of Rheumatoid Arthritis, Lupus, and Scleroderma.  These classic disorders occur because of an increase in antibody formation as a result of a high T-helper/T-suppressor ratio.  T-helper/T-suppressor ratios were returned to normal in three months when Thymic Protein A was used in patients with Rheumatoid Arthritis. Thymic protein use has shown significant improvements in the treatment of Chronic Fatigue, Cold and Flu, Fibromyaliga, Lupus Erythematosus, and Scleroderma.

There have been studies to determine if the use of thymic protein affects lymphocytes (T-cell), a type of white blood cell, plays in periodontal disease.  Neutrophils, another type of white blood cell, have an important role fighting infection and bacterial plaque infections in the mouth. This is especially important to people who have diabetes and the geriatric population because they are the most likely to have depressed levels of neutrophils. Neutrophil growth is encouraged by lymphocytes, which are in turn encouraged by thymic proteins.  Because of this relationship, lymphocytes have a major part in resisting periodontal disease, which can cause heart disease.

The bottom line is, our immune system ages over time just like the rest of our bodies. Add stress, medications, poor eating habits, environmental factors, and genetics to the mix, and it’s quite remarkable that we fend off as many illnesses as we do. However, at the source of healthy immune function we have to produce the correct cells to control inflammation and fight disease. To mature those cells, we need Thymic Protein A, which diminishes over time, as our thymic gland shrinks drastically with age.

Fortunately research has shown that supplementing thymic protein allows the immune system to mature the T-cells needed to its job. ProBoost Direct offers packets with 12 trillion molecules of  Thymic Protein A.

At ProBoost Direct, we are passionate about immune system support! To order ProBoost just give us a click.

Immune System Dysfunction and Thymic Protein A – Part 1

Immune System Dysfunction and Thymic Protein AOver 120 million Americans – one third of the population – are affected by a variety of health robbing dysfunctions of the immune system.  Several disorders and diseases that can result from immune dysfunction are:

It is impossible to accurately estimate the costs of immune dysfunction in terms of lost time at work, health care and prescription bills, not to mention the reduction in quality of life, but it’s not hard to image how huge the costs are given how many people are affected. Unfortunately, instead of looking for the origin of immune system dysfunction, enormous amounts of time and money are spent treating the resulting symptoms and illness – too often ineffectively.

One reason the immune system becomes dysfunctional is due to combined attacks.  When the immune system is suppressed or overworked, and the next infection, allergen or source of inflammation appears, it can be overwhelmed or unable to respond to the new threat.  Ideally, immune function is optimal in order to properly respond to infection, inflammation, or dangerous cells like cancer and tumors. If not, a new threat may emerge and the immune system may over or under-react. For example, chronic low-grade infections and autoimmune disorders occurring simultaneously are not uncommon when the immune system is dysfunctional.

Enter the Thymus Gland. Think of the thymus as the “brain” of the immune system. It is located below the breastbone and manufactures many diverse polypeptides that “program” some of the immune cells, which begin in the bone marrow.  These are called B-cell lymphocytes (white blood cells), which are encoded in the bone marrow and sent to the thymus for “instructions.” Other immune cells mature in the thymus gland by interacting with Thymic Protein A (TPA). Those are the T-lymphocytes (T-Cells), which patrol the body at all times, looking for threats. In order for the T-Cell to carry out its particular function, the receptor on the surface of the T-Cells links with the matching Thymic Protein A becoming immune-competent.

T-4 (CD4) helper cells and the T-8 (CD8) that differentiates into killer and suppressor cells are the two major types of T-Cells. The T-4 cells induce killer and suppressor cells and stimulate B-Cells to make antibodies and macrophages that eat pathogens like cancer cells. Killer cells kill.  They are immune-competent and can recognize tumor cells and cells that are virally infected. The killer cells attack the deviant cells.  Occasionally, killer cells will attack self-tissue, but the immune-competent suppressor cells will intercede to halt the assault if the immune system is optimal.

When the immune system is functioning correctly, the thymus makes proteins that “program” T-cells to start and stop immune response. However, the thymus shrinks over time and eventually ceases to produce the proteins essential to sustain immune balance by maturing new or replacing dysfunctional T-cells. Thymic gland atrophy is a function of aging, but can also be affected by a combination of elements, such as: genetic flaws, stress, disease, allergens, obesity, repeated exposure to toxic substances, medications, and a diet high in inflammation forming foods leading to chronic inflammation.

What if it were possible to regain more vitality, more health? Fortunately, now the immune system can be supplemented with the use of ProBoost Thymic Protein A

Next: Part 2 – Immune Dysfunction: Treatment at the Source

Fibromyalgia and ProBoost

Fibromyalgia and ProBoost – Reducing Inflammation

Inflammation and Fibromyalgia painFibromyalgia is considered the second most common rheumatologic disorder, next to osteoarthritis. It is a disorder that causes severe, chronic pain throughout the body at trigger points, as well as severe chronic fatigue with is also found in Lupus and Lyme disease suffers. Secondary symptoms include sore throat, tender nodes, cognitive difficulty and headache and sleep difficulties.

Despite affecting millions, researchers do not fully understand its cause. It is thought to be caused by dysfunction at the hypothalamic-pituitary axes, a control center for endocrine and immunomodulation.

Additionally, several autoimmune mechanisms have been associated with fibromyalgia and the thymus plays a critical role in mediating these. An imbalance between two lymphocytes which mature in the thymus, Th1 and Th2, and their local effects is thought to cause many of the symptoms associated with this disease. Th1 and Th2 cells are self-regulating. Th1 cells promote the maturation of additional Th1 cells, while suppressing the maturation of Th2 cells. Th2 self-regulates in the same way.

However, Th1 cells have a pro-inflammatory effect, and inflammation is the leading cause of pain. An imbalance which promotes Th1 maturation and suppresses Th2 maturation will lead to the inflammation and pain characteristic of fibromyalgia.

The thymus’ role is to maintain the appropriate balance between these two cell types. It does this though the action of cytokines (interleukins), chemicals which control the maturation process. Cells within the thymus secreting Interleukin-10 (IL-10) will suppress Th1 formation and promote Th2 formation. Cells secrete Interleukin-12 (IL-12) or another cytokine known as Tumor Necrosis Factor-alpha (TNF-a), will promote Th1 formation and suppress Th2 formation. In this way, the thymus is able to regulate the inflammatory response properly.

But what happens when the thymus is unable to regulate the balance of the Th1 and Th2 and inflammation is not confined to an appropriate response? Science now knows that inflammation is at the root of the disease process and autoimmune dysfunction. This results in a host of potential medical problems like heart disease, cancer, Crohn’s or autoimmune issues like fibromyalgia and arthritis.  As we age, the thymus shrinks, producing less and less Thymic Protein A essential to bringing new T-cells online. That means it loses its ability to mature new T-cells and regulate the existing ones.

This is where ProBoost Thymic Protein A (TPA) may help. By supplementing TPA in the correct manner, the thymus gland is able to mature new T-cells, which supports proper immune system function and in turn helps to regulate the inflammation process. Since fibromyalgia is characterized by pain and pain is linked to inflammation, it has been found by people suffering from fibromyalgia that TPA can be beneficial and in some cases produces very noticable relief.

In the acute stage of fibromyalgia or any critical immune dyficent response, taking ProBoost 3 times daily is suggested. When pain, inflammation, infection or low white blood cell count is controlled, the amount can be reduced to 1-2 times daily according to what works for each person.

For more information, questions or to order ProBoost, see our website at ProBoost Direct.