Systemic lupus erythematosus is a chronic, sometimes life-threatening autoimmune disease that often affects women of childbearing age but can affect both men and children. Lupus classically presents with fever, rash, and joint pain.
Other symptoms of lupus include fatigue or weight changes. One of the rashes of lupus, the malar rash, is irritated by direct sun exposure. In children and adults, lupus can cause kidney disease. Persons with lupus often are genetically predisposed by having a family history of the disease.
Lupus affects multiple organs in the body. It can affect the skin, joints, kidneys, brain, bloodstream, and eyes. It is due to the hyperactive immune system producing antibodies that cause inflammation and also lead to immune attack against the body’s own tissues.
Defective T cells are thought to play a role in lupus. T cells in patients with lupus are defective in signaling interleukin-2 (IL-2). Because of this defective signaling, other immune system components are affected, including B cell help, CD8 cytotoxicity, immune cell migration and adhesion.
It is still unclear how these immune defects contribute to the clinical manifestations of lupus. There exists a logical argument for supporting the immune system with a supplement for Lupus, ProBoost – thymic protein A – that have been shown to stimulate T cell production and have a long history of safety.
Treatment for lupus depends on the organ system manifestation. For treatment of the skin rash, it is recommended to wear sunscreen. Smoking cessation, exercise, anti-inflammatory dietary changes and immunizations are recommended. In general, treatment of lupus involves immunosuppression therapies, which help decrease the immune system’s attack against the person’s organs. These include non-steroidal anti-inflammatory drugs (NSAIDs) and short-term course of corticosteroids.