Fibromyalgia and ProBoost – Reducing Inflammation
Fibromyalgia is considered the second most common rheumatologic disorder, next to osteoarthritis. It is a disorder that causes severe, chronic pain throughout the body at trigger points, as well as severe chronic fatigue with is also found in Lupus and Lyme disease suffers. Secondary symptoms include sore throat, tender nodes, cognitive difficulty and headache and sleep difficulties.
Despite affecting millions, researchers do not fully understand its cause. It is thought to be caused by dysfunction at the hypothalamic-pituitary axes, a control center for endocrine and immunomodulation.
Additionally, several autoimmune mechanisms have been associated with fibromyalgia and the thymus plays a critical role in mediating these. An imbalance between two lymphocytes which mature in the thymus, Th1 and Th2, and their local effects is thought to cause many of the symptoms associated with this disease. Th1 and Th2 cells are self-regulating. Th1 cells promote the maturation of additional Th1 cells, while suppressing the maturation of Th2 cells. Th2 self-regulates in the same way.
However, Th1 cells have a pro-inflammatory effect, and inflammation is the leading cause of pain. An imbalance which promotes Th1 maturation and suppresses Th2 maturation will lead to the inflammation and pain characteristic of fibromyalgia.
The thymus’ role is to maintain the appropriate balance between these two cell types. It does this though the action of cytokines (interleukins), chemicals which control the maturation process. Cells within the thymus secreting Interleukin-10 (IL-10) will suppress Th1 formation and promote Th2 formation. Cells secrete Interleukin-12 (IL-12) or another cytokine known as Tumor Necrosis Factor-alpha (TNF-a), will promote Th1 formation and suppress Th2 formation. In this way, the thymus is able to regulate the inflammatory response properly.
But what happens when the thymus is unable to regulate the balance of the Th1 and Th2 and inflammation is not confined to an appropriate response? Science now knows that inflammation is at the root of the disease process and autoimmune dysfunction. This results in a host of potential medical problems like heart disease, cancer, Crohn’s or autoimmune issues like fibromyalgia and arthritis. As we age, the thymus shrinks, producing less and less Thymic Protein A essential to bringing new T-cells online. That means it loses its ability to mature new T-cells and regulate the existing ones.
This is where ProBoost Thymic Protein A (TPA) may help. By supplementing TPA in the correct manner, the thymus gland is able to mature new T-cells, which supports proper immune system function and in turn helps to regulate the inflammation process. Since fibromyalgia is characterized by pain and pain is linked to inflammation, it has been found by people suffering from fibromyalgia that TPA can be beneficial and in some cases produces very noticable relief.
In the acute stage of fibromyalgia or any critical immune dyficent response, taking ProBoost 3 times daily is suggested. When pain, inflammation, infection or low white blood cell count is controlled, the amount can be reduced to 1-2 times daily according to what works for each person.
For more information, questions or to order ProBoost, see our website at ProBoost Direct.